Risk factors and phenytoin prophylaxis for early post-traumatic seizures among patients with traumatic brain injury

Background: Post-traumatic seizure is a well-known and serious complication of traumatic brain injury (TBI). The incidence and risk factors vary among study populations. Very little data have been published concerning this in the Malaysian population. The aim of this study was to ascertain the risk...

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Main Authors:	Chan, Kin Hup, Tharakan, John, Pal, Hillol Kanti, Khan, Naeem, Tan, Yew Chin
Format:	Article
Language:	English
Published:	Universiti Sains Malaysia 2010
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/11873/ http://irep.iium.edu.my/11873/ http://irep.iium.edu.my/11873/1/mjms-17-4-036.pdf

id	iium-11873
recordtype	eprints
spelling	iium-118732011-12-27T02:23:52Z http://irep.iium.edu.my/11873/ Risk factors and phenytoin prophylaxis for early post-traumatic seizures among patients with traumatic brain injury Chan, Kin Hup Tharakan, John Pal, Hillol Kanti Khan, Naeem Tan, Yew Chin R Medicine (General) Background: Post-traumatic seizure is a well-known and serious complication of traumatic brain injury (TBI). The incidence and risk factors vary among study populations. Very little data have been published concerning this in the Malaysian population. The aim of this study was to ascertain the risk factors for the development of early post-traumatic seizures among patients with TBI. Methods: This was a prospective observational study, carried out in Hospital Universiti Sains Malaysia, Kubang Kerian, Kelantan, under the Department of Neurosciences. A total of 157 patients, from all age groups, who were diagnosed with TBI were enrolled from June 2007 to December 2007. They were followed-up for 12 months until death or their first post-traumatic seizure. Survival analysis with Kaplan–Meier curves and Cox proportional hazards regression was performed. Results: A total of 11 (7.0%) of the patients developed early post-traumatic seizures. The risk factors for early post-traumatic seizures were young age (P = 0.021, 95% CI 0.806 to 0.982) and intubated patients (P = 0.029, 95% CI 1.194 to 25.913). The incidence of early post-traumatic seizures in the local population was 7.0%. Conclusion: The incidence of early post-traumatic seizures in the local population of Kelantan and Terengganu is comparable to the incidences reported elsewhere. Younger as well as intubated patients were at a higher risk of developing this condition. It may be necessary to give antiepileptic prophylaxis because any seizure could adversely affect morbidity and mortality. However, the study showed that antiepileptic drug was not beneficial in preventing late post-traumatic seizures, but may have a role in preventing early seizures. Universiti Sains Malaysia 2010-10 Article PeerReviewed application/pdf en http://irep.iium.edu.my/11873/1/mjms-17-4-036.pdf Chan, Kin Hup and Tharakan, John and Pal, Hillol Kanti and Khan, Naeem and Tan, Yew Chin (2010) Risk factors and phenytoin prophylaxis for early post-traumatic seizures among patients with traumatic brain injury. Malaysian Journal of Medical Sciences , 17 (4). pp. 36-43. ISSN 1394-195X http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216189/?tool=pubmed
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Chan, Kin Hup Tharakan, John Pal, Hillol Kanti Khan, Naeem Tan, Yew Chin Risk factors and phenytoin prophylaxis for early post-traumatic seizures among patients with traumatic brain injury
description	Background: Post-traumatic seizure is a well-known and serious complication of traumatic brain injury (TBI). The incidence and risk factors vary among study populations. Very little data have been published concerning this in the Malaysian population. The aim of this study was to ascertain the risk factors for the development of early post-traumatic seizures among patients with TBI. Methods: This was a prospective observational study, carried out in Hospital Universiti Sains Malaysia, Kubang Kerian, Kelantan, under the Department of Neurosciences. A total of 157 patients, from all age groups, who were diagnosed with TBI were enrolled from June 2007 to December 2007. They were followed-up for 12 months until death or their first post-traumatic seizure. Survival analysis with Kaplan–Meier curves and Cox proportional hazards regression was performed. Results: A total of 11 (7.0%) of the patients developed early post-traumatic seizures. The risk factors for early post-traumatic seizures were young age (P = 0.021, 95% CI 0.806 to 0.982) and intubated patients (P = 0.029, 95% CI 1.194 to 25.913). The incidence of early post-traumatic seizures in the local population was 7.0%. Conclusion: The incidence of early post-traumatic seizures in the local population of Kelantan and Terengganu is comparable to the incidences reported elsewhere. Younger as well as intubated patients were at a higher risk of developing this condition. It may be necessary to give antiepileptic prophylaxis because any seizure could adversely affect morbidity and mortality. However, the study showed that antiepileptic drug was not beneficial in preventing late post-traumatic seizures, but may have a role in preventing early seizures.
format	Article
author	Chan, Kin Hup Tharakan, John Pal, Hillol Kanti Khan, Naeem Tan, Yew Chin
author_facet	Chan, Kin Hup Tharakan, John Pal, Hillol Kanti Khan, Naeem Tan, Yew Chin
author_sort	Chan, Kin Hup
title	Risk factors and phenytoin prophylaxis for early post-traumatic seizures among patients with traumatic brain injury
title_short	Risk factors and phenytoin prophylaxis for early post-traumatic seizures among patients with traumatic brain injury
title_full	Risk factors and phenytoin prophylaxis for early post-traumatic seizures among patients with traumatic brain injury
title_fullStr	Risk factors and phenytoin prophylaxis for early post-traumatic seizures among patients with traumatic brain injury
title_full_unstemmed	Risk factors and phenytoin prophylaxis for early post-traumatic seizures among patients with traumatic brain injury
title_sort	risk factors and phenytoin prophylaxis for early post-traumatic seizures among patients with traumatic brain injury
publisher	Universiti Sains Malaysia
publishDate	2010
url	http://irep.iium.edu.my/11873/ http://irep.iium.edu.my/11873/ http://irep.iium.edu.my/11873/1/mjms-17-4-036.pdf
first_indexed	2023-09-18T20:21:08Z
last_indexed	2023-09-18T20:21:08Z
_version_	1777408114076680192

Risk factors and phenytoin prophylaxis for early post-traumatic seizures among patients with traumatic brain injury

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