Beneficial effect of the leaves of Murraya koenigii (Linn.) Spreng (Rutaceae) on diabetes-induced renal damage in vivo

Ethnopharmacological relevance: Murraya koenigii (Linn.) Spreng (curry leaf) is widely used as a nephroprotective agent in kidney’s infirmities among diabetics by the traditional practitioners in Malaysia. However, the latter role of curry leaf has been grossly under reported and is yet to receive...

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Main Authors:	Yankuzo, Hassan, Ahmed, Qamar Uddin, Imam Santosa , Rahajoe, Akter, Seikh Farid Uddin, A.Talib, Norlelawati
Format:	Article
Language:	English
Published:	Elsevier Ireland Ltd 2011
Subjects:	RA Public aspects of medicine RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/11474/ http://irep.iium.edu.my/11474/ http://irep.iium.edu.my/11474/ http://irep.iium.edu.my/11474/1/2011____2___Effect_of_Murraya_Koenigi_Ethnopharmacology.pdf

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recordtype	eprints
spelling	iium-114742013-06-26T07:10:55Z http://irep.iium.edu.my/11474/ Beneficial effect of the leaves of Murraya koenigii (Linn.) Spreng (Rutaceae) on diabetes-induced renal damage in vivo Yankuzo, Hassan Ahmed, Qamar Uddin Imam Santosa , Rahajoe Akter, Seikh Farid Uddin A.Talib, Norlelawati RA Public aspects of medicine RS Pharmacy and materia medica Ethnopharmacological relevance: Murraya koenigii (Linn.) Spreng (curry leaf) is widely used as a nephroprotective agent in kidney’s infirmities among diabetics by the traditional practitioners in Malaysia. However, the latter role of curry leaf has been grossly under reported and is yet to receive proper scientific evaluation. Aim of the study: The present study was designed to investigate the beneficial effect of the leaves of Murraya koenigii (Linn.) on diabetes-induced renal damage in vivo with regard to prove its efficacy by local traditional practitioners in the treatment of kidney frailties in diabetics. Materials and methods: Aqueous (AQ) extract of the leaves of Murraya koenigii (Linn.) was administered to both normal and streptozotocin (STZ) induced diabetic male rats (Sprague–Dawley strain). Animals were divided into six groups (n = 6) and treated with variable dose levels ofAQextract (200 and 400 mg/kg body weight/day) for 30 days. At the end of 30 days, animals were sacrificed, blood was collected, processed and stored at −70 ◦C for the zestimation of serum urea and creatinine, changes in plasma antioxidant capacity by FRAP assay, and glutathione peroxidase levels, in the normal and STZ-induced diabetic rats. Histological changes of the kidneys of these animals were also evaluated by light microscopy to determine the beneficial effect of the leaves. Results: Daily oral administration of variable dose levels of theAQextract for 30 days, produced significant dose dependant decrease in serum urea and creatinine levels (p < 0.001), and marked increase in the levels of plasma antioxidant capacity (p < 0.01) in diabetic treated rats, compared to the control (nondiabetic) subjects. However, the normal treated rats showed minimal variation in these parameters in comparison to normal controls. Histological studies of the kidneys of these animals showed comparable tissue regeneration by the AQ extract. Conclusion: The results of our study scientifically support the traditional belief for using the leaves of Murraya koenigii (Linn.) as adjuvant, in the treatment of pain disorders related to renal impairments among diabetics. Elsevier Ireland Ltd 2011-02-24 Article PeerReviewed application/pdf en http://irep.iium.edu.my/11474/1/2011____2___Effect_of_Murraya_Koenigi_Ethnopharmacology.pdf Yankuzo, Hassan and Ahmed, Qamar Uddin and Imam Santosa , Rahajoe and Akter, Seikh Farid Uddin and A.Talib, Norlelawati (2011) Beneficial effect of the leaves of Murraya koenigii (Linn.) Spreng (Rutaceae) on diabetes-induced renal damage in vivo. Journal of Ethnopharmacology, 135 (1). pp. 88-94. ISSN 0378-8741 http://www.sciencedirect.com/science/article/pii/S037887411100105X 10.1016/j.jep.2011.02.020
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RA Public aspects of medicine RS Pharmacy and materia medica
spellingShingle	RA Public aspects of medicine RS Pharmacy and materia medica Yankuzo, Hassan Ahmed, Qamar Uddin Imam Santosa , Rahajoe Akter, Seikh Farid Uddin A.Talib, Norlelawati Beneficial effect of the leaves of Murraya koenigii (Linn.) Spreng (Rutaceae) on diabetes-induced renal damage in vivo
description	Ethnopharmacological relevance: Murraya koenigii (Linn.) Spreng (curry leaf) is widely used as a nephroprotective agent in kidney’s infirmities among diabetics by the traditional practitioners in Malaysia. However, the latter role of curry leaf has been grossly under reported and is yet to receive proper scientific evaluation. Aim of the study: The present study was designed to investigate the beneficial effect of the leaves of Murraya koenigii (Linn.) on diabetes-induced renal damage in vivo with regard to prove its efficacy by local traditional practitioners in the treatment of kidney frailties in diabetics. Materials and methods: Aqueous (AQ) extract of the leaves of Murraya koenigii (Linn.) was administered to both normal and streptozotocin (STZ) induced diabetic male rats (Sprague–Dawley strain). Animals were divided into six groups (n = 6) and treated with variable dose levels ofAQextract (200 and 400 mg/kg body weight/day) for 30 days. At the end of 30 days, animals were sacrificed, blood was collected, processed and stored at −70 ◦C for the zestimation of serum urea and creatinine, changes in plasma antioxidant capacity by FRAP assay, and glutathione peroxidase levels, in the normal and STZ-induced diabetic rats. Histological changes of the kidneys of these animals were also evaluated by light microscopy to determine the beneficial effect of the leaves. Results: Daily oral administration of variable dose levels of theAQextract for 30 days, produced significant dose dependant decrease in serum urea and creatinine levels (p < 0.001), and marked increase in the levels of plasma antioxidant capacity (p < 0.01) in diabetic treated rats, compared to the control (nondiabetic) subjects. However, the normal treated rats showed minimal variation in these parameters in comparison to normal controls. Histological studies of the kidneys of these animals showed comparable tissue regeneration by the AQ extract. Conclusion: The results of our study scientifically support the traditional belief for using the leaves of Murraya koenigii (Linn.) as adjuvant, in the treatment of pain disorders related to renal impairments among diabetics.
format	Article
author	Yankuzo, Hassan Ahmed, Qamar Uddin Imam Santosa , Rahajoe Akter, Seikh Farid Uddin A.Talib, Norlelawati
author_facet	Yankuzo, Hassan Ahmed, Qamar Uddin Imam Santosa , Rahajoe Akter, Seikh Farid Uddin A.Talib, Norlelawati
author_sort	Yankuzo, Hassan
title	Beneficial effect of the leaves of Murraya koenigii (Linn.) Spreng (Rutaceae) on diabetes-induced renal damage in vivo
title_short	Beneficial effect of the leaves of Murraya koenigii (Linn.) Spreng (Rutaceae) on diabetes-induced renal damage in vivo
title_full	Beneficial effect of the leaves of Murraya koenigii (Linn.) Spreng (Rutaceae) on diabetes-induced renal damage in vivo
title_fullStr	Beneficial effect of the leaves of Murraya koenigii (Linn.) Spreng (Rutaceae) on diabetes-induced renal damage in vivo
title_full_unstemmed	Beneficial effect of the leaves of Murraya koenigii (Linn.) Spreng (Rutaceae) on diabetes-induced renal damage in vivo
title_sort	beneficial effect of the leaves of murraya koenigii (linn.) spreng (rutaceae) on diabetes-induced renal damage in vivo
publisher	Elsevier Ireland Ltd
publishDate	2011
url	http://irep.iium.edu.my/11474/ http://irep.iium.edu.my/11474/ http://irep.iium.edu.my/11474/ http://irep.iium.edu.my/11474/1/2011____2___Effect_of_Murraya_Koenigi_Ethnopharmacology.pdf
first_indexed	2023-09-18T20:20:47Z
last_indexed	2023-09-18T20:20:47Z
_version_	1777408092575629312

Beneficial effect of the leaves of Murraya koenigii (Linn.) Spreng (Rutaceae) on diabetes-induced renal damage in vivo

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