Mnemonic effects of Fixed Oil of Black Cumin (Nigella sativa) seeds on aged rats with memory impairment

Introduction: Memory and learning impairments in elderly remain an unsolved problem especially to those with vascular risk factors that accelerate the oxidative stress associated with aging. Fixed oil of Nigella sativa NSO (black cumin) has revealed considerable antioxidant, anti-inflammatory and im...

Full description

Bibliographic Details
Main Authors:	Azzubaidi, Marwan Saad, A.Talib, Norlelawati, Saxena, Anil Kumar, Ahmed, Qamar Uddin
Format:	Conference or Workshop Item
Language:	English English English
Published:	2011
Subjects:	R Medicine (General) RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/11206/ http://irep.iium.edu.my/11206/ http://irep.iium.edu.my/11206/1/Mnemonic_effects_of_NSO_on_Aged_rats.ppsx http://irep.iium.edu.my/11206/2/Abstract_2011_pp76.jpg http://irep.iium.edu.my/11206/3/Malay_Australia_Research_Colloquium_2011.jpg

id	iium-11206
recordtype	eprints
spelling	iium-112062012-12-17T06:24:52Z http://irep.iium.edu.my/11206/ Mnemonic effects of Fixed Oil of Black Cumin (Nigella sativa) seeds on aged rats with memory impairment Azzubaidi, Marwan Saad A.Talib, Norlelawati Saxena, Anil Kumar Ahmed, Qamar Uddin R Medicine (General) RS Pharmacy and materia medica Introduction: Memory and learning impairments in elderly remain an unsolved problem especially to those with vascular risk factors that accelerate the oxidative stress associated with aging. Fixed oil of Nigella sativa NSO (black cumin) has revealed considerable antioxidant, anti-inflammatory and immunomodulatory properties that may prevent or arrest the deterioration of cognitive brain function. Two vessel occlusion (2VO) surgery is broadly used to create cerebral hypoperfusion for studying cognitive impairment in rats. Objective: In this study Morris water maze (MWM) was used to compare the memory and learning performance of rats with memory and learning deficits induced by 2VO surgery with those orally treated with the NSO as well as with healthy sham control group. Methodology: Sixty rats were recruited in this study. Thirty animals were assigned for long term memory (LTM) test and a similar number was assigned for short term memory (STM) and learning (working memory) tests. Each of these main groups was subdivided into three subgroups each with ten rats. The first was the untreated 2VO, the second was the untreated sham control and the third was the orally NSO treated 2VO group. Results: For LTM and STM MWM test, both Sham control and NSO treated groups showed significantly better performance as compared to untreated 2VO group, confirmed with probe memory test one day later. For Working Memory MWM test, NSO treated groups had significantly lower escape latency time and total distance travelled (p<0.01) as compared to untreated 2VO on three successive test days. Conclusion: The seeds of Nigella sativa may have potential memory and learning enhancing activity and a prospective neuroprotective effect that requires further investigations on brain tissue probably through collaborative work with researchers from USM, University of Sydney or University of Queenland that could enable us to unveil the neuroprotective potential of Nigella sativa fixed oil. Keywords: Morris water maze, rats,2VO, memory, learning, Nigella sativa fixed oil. 2011-09-19 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/11206/1/Mnemonic_effects_of_NSO_on_Aged_rats.ppsx application/pdf en http://irep.iium.edu.my/11206/2/Abstract_2011_pp76.jpg application/pdf en http://irep.iium.edu.my/11206/3/Malay_Australia_Research_Colloquium_2011.jpg Azzubaidi, Marwan Saad and A.Talib, Norlelawati and Saxena, Anil Kumar and Ahmed, Qamar Uddin (2011) Mnemonic effects of Fixed Oil of Black Cumin (Nigella sativa) seeds on aged rats with memory impairment. In: Malaysia-Australia Research Colloquium on Exercise, Nutrition, Health and Wellness, 19th -21st september., Penang. http://www.amdi.usm.edu.my/marc
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	R Medicine (General) RS Pharmacy and materia medica
spellingShingle	R Medicine (General) RS Pharmacy and materia medica Azzubaidi, Marwan Saad A.Talib, Norlelawati Saxena, Anil Kumar Ahmed, Qamar Uddin Mnemonic effects of Fixed Oil of Black Cumin (Nigella sativa) seeds on aged rats with memory impairment
description	Introduction: Memory and learning impairments in elderly remain an unsolved problem especially to those with vascular risk factors that accelerate the oxidative stress associated with aging. Fixed oil of Nigella sativa NSO (black cumin) has revealed considerable antioxidant, anti-inflammatory and immunomodulatory properties that may prevent or arrest the deterioration of cognitive brain function. Two vessel occlusion (2VO) surgery is broadly used to create cerebral hypoperfusion for studying cognitive impairment in rats. Objective: In this study Morris water maze (MWM) was used to compare the memory and learning performance of rats with memory and learning deficits induced by 2VO surgery with those orally treated with the NSO as well as with healthy sham control group. Methodology: Sixty rats were recruited in this study. Thirty animals were assigned for long term memory (LTM) test and a similar number was assigned for short term memory (STM) and learning (working memory) tests. Each of these main groups was subdivided into three subgroups each with ten rats. The first was the untreated 2VO, the second was the untreated sham control and the third was the orally NSO treated 2VO group. Results: For LTM and STM MWM test, both Sham control and NSO treated groups showed significantly better performance as compared to untreated 2VO group, confirmed with probe memory test one day later. For Working Memory MWM test, NSO treated groups had significantly lower escape latency time and total distance travelled (p<0.01) as compared to untreated 2VO on three successive test days. Conclusion: The seeds of Nigella sativa may have potential memory and learning enhancing activity and a prospective neuroprotective effect that requires further investigations on brain tissue probably through collaborative work with researchers from USM, University of Sydney or University of Queenland that could enable us to unveil the neuroprotective potential of Nigella sativa fixed oil. Keywords: Morris water maze, rats,2VO, memory, learning, Nigella sativa fixed oil.
format	Conference or Workshop Item
author	Azzubaidi, Marwan Saad A.Talib, Norlelawati Saxena, Anil Kumar Ahmed, Qamar Uddin
author_facet	Azzubaidi, Marwan Saad A.Talib, Norlelawati Saxena, Anil Kumar Ahmed, Qamar Uddin
author_sort	Azzubaidi, Marwan Saad
title	Mnemonic effects of Fixed Oil of Black Cumin (Nigella sativa) seeds on aged rats with memory impairment
title_short	Mnemonic effects of Fixed Oil of Black Cumin (Nigella sativa) seeds on aged rats with memory impairment
title_full	Mnemonic effects of Fixed Oil of Black Cumin (Nigella sativa) seeds on aged rats with memory impairment
title_fullStr	Mnemonic effects of Fixed Oil of Black Cumin (Nigella sativa) seeds on aged rats with memory impairment
title_full_unstemmed	Mnemonic effects of Fixed Oil of Black Cumin (Nigella sativa) seeds on aged rats with memory impairment
title_sort	mnemonic effects of fixed oil of black cumin (nigella sativa) seeds on aged rats with memory impairment
publishDate	2011
url	http://irep.iium.edu.my/11206/ http://irep.iium.edu.my/11206/ http://irep.iium.edu.my/11206/1/Mnemonic_effects_of_NSO_on_Aged_rats.ppsx http://irep.iium.edu.my/11206/2/Abstract_2011_pp76.jpg http://irep.iium.edu.my/11206/3/Malay_Australia_Research_Colloquium_2011.jpg
first_indexed	2023-09-18T20:20:33Z
last_indexed	2023-09-18T20:20:33Z
_version_	1777408077571555328

Mnemonic effects of Fixed Oil of Black Cumin (Nigella sativa) seeds on aged rats with memory impairment

Similar Items