Anti-hyperglycemic activity of the leaves of Tetracera scandens Linn. Merr. (Dilleniaceae) in alloxan induced diabetic rats

Aim of the study: The present study was aimed to investigate the anti-diabetic potential of the leaves of Tetracera scandens Linn. Merr. (Dilleniaceae) in vivo with regard to prove its efficacy by local herbalists in the treatment of diabetes frailties. Materials and methods: Crude aqueous (AQ) and...

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Main Authors:	Umar, Abdulrashid, Ahmed, Qamar Uddin, Muhammad, Bala Yauri, Dogarai, Bashar Bello S., Mat So'ad, Siti Zaiton
Format:	Article
Language:	English
Published:	Elsevier Science, Amsterdam, Netherlands. 2010
Subjects:	QD Chemistry
Online Access:	http://irep.iium.edu.my/11099/ http://irep.iium.edu.my/11099/ http://irep.iium.edu.my/11099/ http://irep.iium.edu.my/11099/1/Anti-hyperglycemic_activity_of_the_leaves_of_Tetracera_scandens_Linn._Merr..pdf

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spelling	iium-110992013-07-27T08:06:46Z http://irep.iium.edu.my/11099/ Anti-hyperglycemic activity of the leaves of Tetracera scandens Linn. Merr. (Dilleniaceae) in alloxan induced diabetic rats Umar, Abdulrashid Ahmed, Qamar Uddin Muhammad, Bala Yauri Dogarai, Bashar Bello S. Mat So'ad, Siti Zaiton QD Chemistry Aim of the study: The present study was aimed to investigate the anti-diabetic potential of the leaves of Tetracera scandens Linn. Merr. (Dilleniaceae) in vivo with regard to prove its efficacy by local herbalists in the treatment of diabetes frailties. Materials and methods: Crude aqueous (AQ) and methanol (MEOH) extracts of the leaves of T. scandens L. were administered to both normal and alloxan induced diabetic male albino rats (Wistar strain). The blood glucose levels were measured at 0, 2, 4, 6 and 8 h after oral administration of AQ and MEOH extracts. Results: Significant reduction in glucose was observed in fasting blood glucose levels in the treated diabetic rats without causing any hypoglycemic effect compared to normal rats. Both polar extracts of the leaves of T. scandens L. exhibited significant anti-hyperglycemic activity at different doses and intervals. The highest anti-hyperglycemic effect (62.5%) was observed by the AQ extract at 0.25 g/kg body weight (b.w.) and MEOH extract (36.5%) at 0.5 g/kg b.w. after 8 h. The significant anti-hyperglycemic activity was found to be comparable with a known oral synthetic hypoglycemic drug, glibenclamide 0.25 mg/kg b.w. Conclusion: This study provides scientific evidence that the leaves of T. scandens L. have anti-diabetic efficacy and justifies its utility by local herbalists. However, more experiments at the clinical levels are required to confirm the utility of this plant by traditional practitioners in the management of diabetes mellitus. Keywords: Tetracera scandens L.; Dilleniaceae; Alloxan induced diabetic rats; Anti-hyperglycemic activity in vivo Elsevier Science, Amsterdam, Netherlands. 2010-06 Article PeerReviewed application/pdf en http://irep.iium.edu.my/11099/1/Anti-hyperglycemic_activity_of_the_leaves_of_Tetracera_scandens_Linn._Merr..pdf Umar, Abdulrashid and Ahmed, Qamar Uddin and Muhammad, Bala Yauri and Dogarai, Bashar Bello S. and Mat So'ad, Siti Zaiton (2010) Anti-hyperglycemic activity of the leaves of Tetracera scandens Linn. Merr. (Dilleniaceae) in alloxan induced diabetic rats. Journal of Ethnopharmacology, 131 (-). pp. 140-145. ISSN 0378-8741 http://www.elsevier.com/. DOI: 10.1016/j.jep.2010.06.016.
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QD Chemistry
spellingShingle	QD Chemistry Umar, Abdulrashid Ahmed, Qamar Uddin Muhammad, Bala Yauri Dogarai, Bashar Bello S. Mat So'ad, Siti Zaiton Anti-hyperglycemic activity of the leaves of Tetracera scandens Linn. Merr. (Dilleniaceae) in alloxan induced diabetic rats
description	Aim of the study: The present study was aimed to investigate the anti-diabetic potential of the leaves of Tetracera scandens Linn. Merr. (Dilleniaceae) in vivo with regard to prove its efficacy by local herbalists in the treatment of diabetes frailties. Materials and methods: Crude aqueous (AQ) and methanol (MEOH) extracts of the leaves of T. scandens L. were administered to both normal and alloxan induced diabetic male albino rats (Wistar strain). The blood glucose levels were measured at 0, 2, 4, 6 and 8 h after oral administration of AQ and MEOH extracts. Results: Significant reduction in glucose was observed in fasting blood glucose levels in the treated diabetic rats without causing any hypoglycemic effect compared to normal rats. Both polar extracts of the leaves of T. scandens L. exhibited significant anti-hyperglycemic activity at different doses and intervals. The highest anti-hyperglycemic effect (62.5%) was observed by the AQ extract at 0.25 g/kg body weight (b.w.) and MEOH extract (36.5%) at 0.5 g/kg b.w. after 8 h. The significant anti-hyperglycemic activity was found to be comparable with a known oral synthetic hypoglycemic drug, glibenclamide 0.25 mg/kg b.w. Conclusion: This study provides scientific evidence that the leaves of T. scandens L. have anti-diabetic efficacy and justifies its utility by local herbalists. However, more experiments at the clinical levels are required to confirm the utility of this plant by traditional practitioners in the management of diabetes mellitus. Keywords: Tetracera scandens L.; Dilleniaceae; Alloxan induced diabetic rats; Anti-hyperglycemic activity in vivo
format	Article
author	Umar, Abdulrashid Ahmed, Qamar Uddin Muhammad, Bala Yauri Dogarai, Bashar Bello S. Mat So'ad, Siti Zaiton
author_facet	Umar, Abdulrashid Ahmed, Qamar Uddin Muhammad, Bala Yauri Dogarai, Bashar Bello S. Mat So'ad, Siti Zaiton
author_sort	Umar, Abdulrashid
title	Anti-hyperglycemic activity of the leaves of Tetracera scandens Linn. Merr. (Dilleniaceae) in alloxan induced diabetic rats
title_short	Anti-hyperglycemic activity of the leaves of Tetracera scandens Linn. Merr. (Dilleniaceae) in alloxan induced diabetic rats
title_full	Anti-hyperglycemic activity of the leaves of Tetracera scandens Linn. Merr. (Dilleniaceae) in alloxan induced diabetic rats
title_fullStr	Anti-hyperglycemic activity of the leaves of Tetracera scandens Linn. Merr. (Dilleniaceae) in alloxan induced diabetic rats
title_full_unstemmed	Anti-hyperglycemic activity of the leaves of Tetracera scandens Linn. Merr. (Dilleniaceae) in alloxan induced diabetic rats
title_sort	anti-hyperglycemic activity of the leaves of tetracera scandens linn. merr. (dilleniaceae) in alloxan induced diabetic rats
publisher	Elsevier Science, Amsterdam, Netherlands.
publishDate	2010
url	http://irep.iium.edu.my/11099/ http://irep.iium.edu.my/11099/ http://irep.iium.edu.my/11099/ http://irep.iium.edu.my/11099/1/Anti-hyperglycemic_activity_of_the_leaves_of_Tetracera_scandens_Linn._Merr..pdf
first_indexed	2023-09-18T20:20:27Z
last_indexed	2023-09-18T20:20:27Z
_version_	1777408071831650304

Anti-hyperglycemic activity of the leaves of Tetracera scandens Linn. Merr. (Dilleniaceae) in alloxan induced diabetic rats

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