Growth medium with low serum and transforming growth factor beta 3 promotes better chondrogenesis of bone marrow-derived stem cells in vitro and in vivo

Growth medium with low serum and transforming growth factor beta 3 promotes better chondrogenesis of bone marrow-derived stem cells in vitro and in vivo

Adult mesenchymal stem cells are candidate cells for cartilage tissue engineering due to their ability to undergo chondrogenic differentiation after extensive expansion, and induced with growth factors.1 Sustained delivery of transforming growth factor beta (TGF-ß)3 induces differentiation of human...

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Main Authors: Alfaqeh, Hamoud Hussein Mohammed, Chua, K. Hui, Saim, Aminuddin, Idrus, Ruszymah
Format: Article
Language:English
Published: Riyadh Armed Forces Hospital 2011
Subjects:
R Medicine (General)
Online Access:http://irep.iium.edu.my/11070/
http://irep.iium.edu.my/11070/
http://irep.iium.edu.my/11070/1/Saudi_Med_J_2011_Hamoud_et_al.pdf
id iium-11070
recordtype eprints
spelling iium-110702015-01-15T08:37:22Z http://irep.iium.edu.my/11070/ Growth medium with low serum and transforming growth factor beta 3 promotes better chondrogenesis of bone marrow-derived stem cells in vitro and in vivo Alfaqeh, Hamoud Hussein Mohammed Chua, K. Hui Saim, Aminuddin Idrus, Ruszymah R Medicine (General) Adult mesenchymal stem cells are candidate cells for cartilage tissue engineering due to their ability to undergo chondrogenic differentiation after extensive expansion, and induced with growth factors.1 Sustained delivery of transforming growth factor beta (TGF-ß)3 induces differentiation of human bone marrow-derived stem cells (BMSCs) into chondrocytes.2 Bone marrowderived stem cells undergo chondrogenesis in a variety of culture conditions, and the addition of TGF-ßs has generally enhanced chondrogenesis regardless of culture method.3 "echondrogenic differentiation of BMSCs induced by growth factors, such as TGF-ß3, and insulin like growth factor (IGF)-1 can inhibit the instability of the chondrocyte phenotype, promote extracellular matrix secretion, and maintain cartilage matrix macromolecules during chondrogenesis.4 "e shift from TGF-ß3 to IGF-I at week 3 resulted in a significant increase of cartilage-like extracellular matrix.5 "is study aimed to examine the effect of TGF-ß3 and TGF-ß2 on BMSCs chondrogenesis in vitro and in vivo. Riyadh Armed Forces Hospital 2011-02-28 Article PeerReviewed application/pdf en http://irep.iium.edu.my/11070/1/Saudi_Med_J_2011_Hamoud_et_al.pdf Alfaqeh, Hamoud Hussein Mohammed and Chua, K. Hui and Saim, Aminuddin and Idrus, Ruszymah (2011) Growth medium with low serum and transforming growth factor beta 3 promotes better chondrogenesis of bone marrow-derived stem cells in vitro and in vivo. Saudi Medical Journal, 32 (6). pp. 2-3. ISSN 0379-5284(print), 658-3175(online) http://www.smj.org.sa/
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic R Medicine (General)
spellingShingle R Medicine (General)
Alfaqeh, Hamoud Hussein Mohammed
Chua, K. Hui
Saim, Aminuddin
Idrus, Ruszymah
Growth medium with low serum and transforming growth factor beta 3 promotes better chondrogenesis of bone marrow-derived stem cells in vitro and in vivo
description Adult mesenchymal stem cells are candidate cells for cartilage tissue engineering due to their ability to undergo chondrogenic differentiation after extensive expansion, and induced with growth factors.1 Sustained delivery of transforming growth factor beta (TGF-ß)3 induces differentiation of human bone marrow-derived stem cells (BMSCs) into chondrocytes.2 Bone marrowderived stem cells undergo chondrogenesis in a variety of culture conditions, and the addition of TGF-ßs has generally enhanced chondrogenesis regardless of culture method.3 "echondrogenic differentiation of BMSCs induced by growth factors, such as TGF-ß3, and insulin like growth factor (IGF)-1 can inhibit the instability of the chondrocyte phenotype, promote extracellular matrix secretion, and maintain cartilage matrix macromolecules during chondrogenesis.4 "e shift from TGF-ß3 to IGF-I at week 3 resulted in a significant increase of cartilage-like extracellular matrix.5 "is study aimed to examine the effect of TGF-ß3 and TGF-ß2 on BMSCs chondrogenesis in vitro and in vivo.
format Article
author Alfaqeh, Hamoud Hussein Mohammed
Chua, K. Hui
Saim, Aminuddin
Idrus, Ruszymah
author_facet Alfaqeh, Hamoud Hussein Mohammed
Chua, K. Hui
Saim, Aminuddin
Idrus, Ruszymah
author_sort Alfaqeh, Hamoud Hussein Mohammed
title Growth medium with low serum and transforming growth factor beta 3 promotes better chondrogenesis of bone marrow-derived stem cells in vitro and in vivo
title_short Growth medium with low serum and transforming growth factor beta 3 promotes better chondrogenesis of bone marrow-derived stem cells in vitro and in vivo
title_full Growth medium with low serum and transforming growth factor beta 3 promotes better chondrogenesis of bone marrow-derived stem cells in vitro and in vivo
title_fullStr Growth medium with low serum and transforming growth factor beta 3 promotes better chondrogenesis of bone marrow-derived stem cells in vitro and in vivo
title_full_unstemmed Growth medium with low serum and transforming growth factor beta 3 promotes better chondrogenesis of bone marrow-derived stem cells in vitro and in vivo
title_sort growth medium with low serum and transforming growth factor beta 3 promotes better chondrogenesis of bone marrow-derived stem cells in vitro and in vivo
publisher Riyadh Armed Forces Hospital
publishDate 2011
url http://irep.iium.edu.my/11070/
http://irep.iium.edu.my/11070/
http://irep.iium.edu.my/11070/1/Saudi_Med_J_2011_Hamoud_et_al.pdf
first_indexed 2023-09-18T20:20:26Z
last_indexed 2023-09-18T20:20:26Z
_version_ 1777408070267174912

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