The effect of Aqueous Olive Leaves Extract on the Pancreatic Islets of Streptozotocin Induced Diabetes Mellitus in mice

The objectives of this study were to investigate the effects of the aqueous crude extract of Olea europaea on serum glucose level and histopathological changes in islets of Langerhans in an induced-diabetic mellitus in mice. The experimental recommended 60 male mice were divided into three groups...

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Main Authors:	Al-Badri, Sanarya T., Al-Ani, Imad Matloub Dally, Al-Jashamy, Karim A.
Format:	Article
Language:	English English
Published:	Department of Anatomy, National University of Singapore 2011
Subjects:	QM Human anatomy QP Physiology RB Pathology
Online Access:	http://irep.iium.edu.my/11023/ http://irep.iium.edu.my/11023/1/The_Effect_of_Aqueous_Olive_Leaves_Extract_on_the_Pancreatic_Islets_of.pdf http://irep.iium.edu.my/11023/2/The_Effect_of_Aqueous_Olive_Leaves_Extract_on_the_Pancreatic_Islets_of.pdf

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spelling	iium-110232015-12-18T02:46:58Z http://irep.iium.edu.my/11023/ The effect of Aqueous Olive Leaves Extract on the Pancreatic Islets of Streptozotocin Induced Diabetes Mellitus in mice Al-Badri, Sanarya T. Al-Ani, Imad Matloub Dally Al-Jashamy, Karim A. QM Human anatomy QP Physiology RB Pathology The objectives of this study were to investigate the effects of the aqueous crude extract of Olea europaea on serum glucose level and histopathological changes in islets of Langerhans in an induced-diabetic mellitus in mice. The experimental recommended 60 male mice were divided into three groups contained 20 mice each. The fi rst group was the control and they were given normal saline pH 7.0. The second group was intraperitoneally injected by a dose of 100mg/Kg of STZ and 10% glucose instead of normal drinking water over the 24 hours followed the treatment. The third group was injected intraperitoneally with 100mg/kg STZ and orally given 0.33g/ Kg aqueous extract of olive leaves everyday for four weeks. Blood specimens were collected, and the serum separated and stored at 4OC until it is used. The animals were dissected and the pancreatic tissues were obtained, the tissue specimens were fi xed in the Boun’s solution for 24 hr, and processed for histological studies. There was a signifi cant increase in blood glucose level of the STZ- diabetic mice by the fi rst week of injection with STZ in comparison with control group. A signifi cant decrease in blood glucose level occurred in the STZ-diabetic group treated with Olea europaea aqueous extract. Islets of langerhans are hypertrophied in the STZ-diabetic group and this hypertrophy showed a signifi cant increased in the average of islets size at the last week, while the treatment with Olea europaea aqueous extract showed a reduction of the islet size compared with the islets of the STZ –diabetic Mice Department of Anatomy, National University of Singapore 2011-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/11023/1/The_Effect_of_Aqueous_Olive_Leaves_Extract_on_the_Pancreatic_Islets_of.pdf application/pdf en http://irep.iium.edu.my/11023/2/The_Effect_of_Aqueous_Olive_Leaves_Extract_on_the_Pancreatic_Islets_of.pdf Al-Badri, Sanarya T. and Al-Ani, Imad Matloub Dally and Al-Jashamy, Karim A. (2011) The effect of Aqueous Olive Leaves Extract on the Pancreatic Islets of Streptozotocin Induced Diabetes Mellitus in mice. Annals of Microscopy, 11. ISSN 0219-2209
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	QM Human anatomy QP Physiology RB Pathology
spellingShingle	QM Human anatomy QP Physiology RB Pathology Al-Badri, Sanarya T. Al-Ani, Imad Matloub Dally Al-Jashamy, Karim A. The effect of Aqueous Olive Leaves Extract on the Pancreatic Islets of Streptozotocin Induced Diabetes Mellitus in mice
description	The objectives of this study were to investigate the effects of the aqueous crude extract of Olea europaea on serum glucose level and histopathological changes in islets of Langerhans in an induced-diabetic mellitus in mice. The experimental recommended 60 male mice were divided into three groups contained 20 mice each. The fi rst group was the control and they were given normal saline pH 7.0. The second group was intraperitoneally injected by a dose of 100mg/Kg of STZ and 10% glucose instead of normal drinking water over the 24 hours followed the treatment. The third group was injected intraperitoneally with 100mg/kg STZ and orally given 0.33g/ Kg aqueous extract of olive leaves everyday for four weeks. Blood specimens were collected, and the serum separated and stored at 4OC until it is used. The animals were dissected and the pancreatic tissues were obtained, the tissue specimens were fi xed in the Boun’s solution for 24 hr, and processed for histological studies. There was a signifi cant increase in blood glucose level of the STZ- diabetic mice by the fi rst week of injection with STZ in comparison with control group. A signifi cant decrease in blood glucose level occurred in the STZ-diabetic group treated with Olea europaea aqueous extract. Islets of langerhans are hypertrophied in the STZ-diabetic group and this hypertrophy showed a signifi cant increased in the average of islets size at the last week, while the treatment with Olea europaea aqueous extract showed a reduction of the islet size compared with the islets of the STZ –diabetic Mice
format	Article
author	Al-Badri, Sanarya T. Al-Ani, Imad Matloub Dally Al-Jashamy, Karim A.
author_facet	Al-Badri, Sanarya T. Al-Ani, Imad Matloub Dally Al-Jashamy, Karim A.
author_sort	Al-Badri, Sanarya T.
title	The effect of Aqueous Olive Leaves Extract on the Pancreatic Islets of Streptozotocin Induced Diabetes Mellitus in mice
title_short	The effect of Aqueous Olive Leaves Extract on the Pancreatic Islets of Streptozotocin Induced Diabetes Mellitus in mice
title_full	The effect of Aqueous Olive Leaves Extract on the Pancreatic Islets of Streptozotocin Induced Diabetes Mellitus in mice
title_fullStr	The effect of Aqueous Olive Leaves Extract on the Pancreatic Islets of Streptozotocin Induced Diabetes Mellitus in mice
title_full_unstemmed	The effect of Aqueous Olive Leaves Extract on the Pancreatic Islets of Streptozotocin Induced Diabetes Mellitus in mice
title_sort	effect of aqueous olive leaves extract on the pancreatic islets of streptozotocin induced diabetes mellitus in mice
publisher	Department of Anatomy, National University of Singapore
publishDate	2011
url	http://irep.iium.edu.my/11023/ http://irep.iium.edu.my/11023/1/The_Effect_of_Aqueous_Olive_Leaves_Extract_on_the_Pancreatic_Islets_of.pdf http://irep.iium.edu.my/11023/2/The_Effect_of_Aqueous_Olive_Leaves_Extract_on_the_Pancreatic_Islets_of.pdf
first_indexed	2023-09-18T20:20:23Z
last_indexed	2023-09-18T20:20:23Z
_version_	1777408067298656256

The effect of Aqueous Olive Leaves Extract on the Pancreatic Islets of Streptozotocin Induced Diabetes Mellitus in mice

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