Histological liver changes in streptozotocin induced diabetic mice

Streptozotocin (STZ) is selectively toxic to cells in the pancreatic islets. It is well known that STZ causes specific death of B cells and induces diabetes mellitus. This study has been conducted to detect the histological changes that could be induced in liver of adult diabetic mice. The experimen...

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Main Authors:	Al-Ani, Imad Matloub Dally, Al-Mishadani, Nu’man S, Muslih, Raad K., Hamoodi , Salim R.
Format:	Article
Language:	English
Published:	Kulliyyah of Medicine, International Islamic University Malaysia 2009
Subjects:	QM Human anatomy QP Physiology RB Pathology
Online Access:	http://irep.iium.edu.my/11004/ http://irep.iium.edu.my/11004/ http://irep.iium.edu.my/11004/1/Histological_Liver_Changes_in_Streptozotocin.mht

id	iium-11004
recordtype	eprints
spelling	iium-110042015-12-18T02:48:46Z http://irep.iium.edu.my/11004/ Histological liver changes in streptozotocin induced diabetic mice Al-Ani, Imad Matloub Dally Al-Mishadani, Nu’man S Muslih, Raad K. Hamoodi , Salim R. QM Human anatomy QP Physiology RB Pathology Streptozotocin (STZ) is selectively toxic to cells in the pancreatic islets. It is well known that STZ causes specific death of B cells and induces diabetes mellitus. This study has been conducted to detect the histological changes that could be induced in liver of adult diabetic mice. The experiments were performed using a single dose of STZ (150mg/Kg. I.P.). Animals were killed two, four and six weeks after injection. The relative percentage of liver weight and liver histology were studied. The results showed several morphological and histological alterations in liver tissues, indicated by increase in the liver percentage of liver weight, glycogen reduction, associated with lipid deposition, inflammatory cells infiltration and Kupffer cells hyperplasia. Furthermore, this study illustrated the worsening of liver histology over a short time in STZ diabetic mice. Kulliyyah of Medicine, International Islamic University Malaysia 2009-06 Article PeerReviewed application/pdf en http://irep.iium.edu.my/11004/1/Histological_Liver_Changes_in_Streptozotocin.mht Al-Ani, Imad Matloub Dally and Al-Mishadani, Nu’man S and Muslih, Raad K. and Hamoodi , Salim R. (2009) Histological liver changes in streptozotocin induced diabetic mice. International Medical Journal Malaysia, 8 (1). ISSN 1823-4631 http://www.e-imj.com/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QM Human anatomy QP Physiology RB Pathology
spellingShingle	QM Human anatomy QP Physiology RB Pathology Al-Ani, Imad Matloub Dally Al-Mishadani, Nu’man S Muslih, Raad K. Hamoodi , Salim R. Histological liver changes in streptozotocin induced diabetic mice
description	Streptozotocin (STZ) is selectively toxic to cells in the pancreatic islets. It is well known that STZ causes specific death of B cells and induces diabetes mellitus. This study has been conducted to detect the histological changes that could be induced in liver of adult diabetic mice. The experiments were performed using a single dose of STZ (150mg/Kg. I.P.). Animals were killed two, four and six weeks after injection. The relative percentage of liver weight and liver histology were studied. The results showed several morphological and histological alterations in liver tissues, indicated by increase in the liver percentage of liver weight, glycogen reduction, associated with lipid deposition, inflammatory cells infiltration and Kupffer cells hyperplasia. Furthermore, this study illustrated the worsening of liver histology over a short time in STZ diabetic mice.
format	Article
author	Al-Ani, Imad Matloub Dally Al-Mishadani, Nu’man S Muslih, Raad K. Hamoodi , Salim R.
author_facet	Al-Ani, Imad Matloub Dally Al-Mishadani, Nu’man S Muslih, Raad K. Hamoodi , Salim R.
author_sort	Al-Ani, Imad Matloub Dally
title	Histological liver changes in streptozotocin induced diabetic mice
title_short	Histological liver changes in streptozotocin induced diabetic mice
title_full	Histological liver changes in streptozotocin induced diabetic mice
title_fullStr	Histological liver changes in streptozotocin induced diabetic mice
title_full_unstemmed	Histological liver changes in streptozotocin induced diabetic mice
title_sort	histological liver changes in streptozotocin induced diabetic mice
publisher	Kulliyyah of Medicine, International Islamic University Malaysia
publishDate	2009
url	http://irep.iium.edu.my/11004/ http://irep.iium.edu.my/11004/ http://irep.iium.edu.my/11004/1/Histological_Liver_Changes_in_Streptozotocin.mht
first_indexed	2023-09-18T20:20:21Z
last_indexed	2023-09-18T20:20:21Z
_version_	1777408065531805696

Histological liver changes in streptozotocin induced diabetic mice

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