Histological findings of ascending urinary tract infections in experimental rats caused by Proteus mirabilis

Proteus mirabilis has previously been shown to be capable of persisting in the rat kidney for up to 8 weeks and induces many physiological changes following a single inoculation of the urinary bladder. The present study examined kidney tissue from infected animals for evi-dence of renal damage. The...

Full description

Bibliographic Details
Main Authors:	Al-Ani, Imad Matloub Dally, Al-Murayati, Hayder Y., Salman, Mohammad O., Ghani, Hameed M.
Format:	Article
Language:	English
Published:	Scientific Publisher of India 2011
Subjects:	QM Human anatomy QR Microbiology RB Pathology
Online Access:	http://irep.iium.edu.my/10724/ http://irep.iium.edu.my/10724/ http://irep.iium.edu.my/10724/1/Histological_findings_of_ascending_urinary.pdf

id	iium-10724
recordtype	eprints
spelling	iium-107242015-12-18T02:45:55Z http://irep.iium.edu.my/10724/ Histological findings of ascending urinary tract infections in experimental rats caused by Proteus mirabilis Al-Ani, Imad Matloub Dally Al-Murayati, Hayder Y. Salman, Mohammad O. Ghani, Hameed M. QM Human anatomy QR Microbiology RB Pathology Proteus mirabilis has previously been shown to be capable of persisting in the rat kidney for up to 8 weeks and induces many physiological changes following a single inoculation of the urinary bladder. The present study examined kidney tissue from infected animals for evi-dence of renal damage. The earliest histologic changes seen on the 2nd and 4th days, consisted of mild cellular sloughing and edema associated with mononuclear infiltration in the me-dulla and to a lesser extent in the cortex. On the 1st and following weeks, tubular atrophy, interstitial fibrosis, and a mononuclear infiltrate had advanced in the renal parenchyma re-sulting in chronic pyelonephritis. The observed renal degenerations with a corresponding ascending bacterial infection in the intra-renal reflux suggest that Proteus mirabilis is capa-ble of producing chronic pyelonephritis in the rats after a single reflux challenge. Scientific Publisher of India 2011-10 Article PeerReviewed application/pdf en http://irep.iium.edu.my/10724/1/Histological_findings_of_ascending_urinary.pdf Al-Ani, Imad Matloub Dally and Al-Murayati, Hayder Y. and Salman, Mohammad O. and Ghani, Hameed M. (2011) Histological findings of ascending urinary tract infections in experimental rats caused by Proteus mirabilis. Biomedical Research, 22 (4). pp. 425-430. ISSN 0970938X http://www.biomedres.org/journal
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QM Human anatomy QR Microbiology RB Pathology
spellingShingle	QM Human anatomy QR Microbiology RB Pathology Al-Ani, Imad Matloub Dally Al-Murayati, Hayder Y. Salman, Mohammad O. Ghani, Hameed M. Histological findings of ascending urinary tract infections in experimental rats caused by Proteus mirabilis
description	Proteus mirabilis has previously been shown to be capable of persisting in the rat kidney for up to 8 weeks and induces many physiological changes following a single inoculation of the urinary bladder. The present study examined kidney tissue from infected animals for evi-dence of renal damage. The earliest histologic changes seen on the 2nd and 4th days, consisted of mild cellular sloughing and edema associated with mononuclear infiltration in the me-dulla and to a lesser extent in the cortex. On the 1st and following weeks, tubular atrophy, interstitial fibrosis, and a mononuclear infiltrate had advanced in the renal parenchyma re-sulting in chronic pyelonephritis. The observed renal degenerations with a corresponding ascending bacterial infection in the intra-renal reflux suggest that Proteus mirabilis is capa-ble of producing chronic pyelonephritis in the rats after a single reflux challenge.
format	Article
author	Al-Ani, Imad Matloub Dally Al-Murayati, Hayder Y. Salman, Mohammad O. Ghani, Hameed M.
author_facet	Al-Ani, Imad Matloub Dally Al-Murayati, Hayder Y. Salman, Mohammad O. Ghani, Hameed M.
author_sort	Al-Ani, Imad Matloub Dally
title	Histological findings of ascending urinary tract infections in experimental rats caused by Proteus mirabilis
title_short	Histological findings of ascending urinary tract infections in experimental rats caused by Proteus mirabilis
title_full	Histological findings of ascending urinary tract infections in experimental rats caused by Proteus mirabilis
title_fullStr	Histological findings of ascending urinary tract infections in experimental rats caused by Proteus mirabilis
title_full_unstemmed	Histological findings of ascending urinary tract infections in experimental rats caused by Proteus mirabilis
title_sort	histological findings of ascending urinary tract infections in experimental rats caused by proteus mirabilis
publisher	Scientific Publisher of India
publishDate	2011
url	http://irep.iium.edu.my/10724/ http://irep.iium.edu.my/10724/ http://irep.iium.edu.my/10724/1/Histological_findings_of_ascending_urinary.pdf
first_indexed	2023-09-18T20:20:07Z
last_indexed	2023-09-18T20:20:07Z
_version_	1777408050054823936

Histological findings of ascending urinary tract infections in experimental rats caused by Proteus mirabilis

Similar Items