Beneficial effects of ginger (Zingiber officinale) on carbohydrate metabolism in streptozotocin-induced diabetic rats

Zingiber officinale (ZO), commonly known as ginger, has been traditionally used in the treatment of diabetes mellitus. Several studies have reported the hypoglycaemic properties of ginger in animal models. The present study evaluated the antihyperglycaemic effect of its aqueous extract administered...

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Main Authors:	Abdulrazaq, Nafiu Bidemi, Cho, Maung Maung, Win, Ni Ni, Zaman, Rahela, Rahman, Mohammad Tariqur
Format:	Article
Language:	English
Published:	Cambridge University Press 2011
Subjects:	QP Physiology
Online Access:	http://irep.iium.edu.my/10548/ http://irep.iium.edu.my/10548/ http://irep.iium.edu.my/10548/ http://irep.iium.edu.my/10548/1/BJN_PUBLICATION_2011.pdf

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spelling	iium-105482013-06-26T07:12:52Z http://irep.iium.edu.my/10548/ Beneficial effects of ginger (Zingiber officinale) on carbohydrate metabolism in streptozotocin-induced diabetic rats Abdulrazaq, Nafiu Bidemi Cho, Maung Maung Win, Ni Ni Zaman, Rahela Rahman, Mohammad Tariqur QP Physiology Zingiber officinale (ZO), commonly known as ginger, has been traditionally used in the treatment of diabetes mellitus. Several studies have reported the hypoglycaemic properties of ginger in animal models. The present study evaluated the antihyperglycaemic effect of its aqueous extract administered orally (daily) in three different doses (100, 300, 500 mg/kg body weight) for a period of 30 d to streptozotocin (STZ)-induced diabetic rats. A dose-dependent antihyperglycaemic effect revealed a decrease of plasma glucose levels by 38 and 68 % on the 15th and 30th day, respectively, after the rats were given 500 mg/kg. The 500 mg/kg ZO significantly (P < 0·05) decreased kidney weight (% body weight) in ZO-treated diabetic rats v. control rats, although the decrease in liver weight (% body weight) was not statistically significant. Kidney glycogen content increased significantly (P < 0·05) while liver and skeletal muscle glycogen content decreased significantly (P < 0·05) in diabetic controls v. normal controls. ZO (500 mg/kg) also significantly decreased kidney glycogen (P < 0·05) and increased liver and skeletal muscle glycogen in STZ-diabetic rats when compared to diabetic controls. Activities of glucokinase, phosphofructokinase and pyruvate kinase in diabetic controls were decreased by 94, 53 and 61 %, respectively, when compared to normal controls; and ZO significantly increased (P < 0·05) those enzymes' activities in STZ-diabetic rats. Therefore, the present study showed that ginger is a potential phytomedicine for the treatment of diabetes through its effects on the activities of glycolytic enzymes Cambridge University Press 2011-11-02 Article PeerReviewed application/pdf en http://irep.iium.edu.my/10548/1/BJN_PUBLICATION_2011.pdf Abdulrazaq, Nafiu Bidemi and Cho, Maung Maung and Win, Ni Ni and Zaman, Rahela and Rahman, Mohammad Tariqur (2011) Beneficial effects of ginger (Zingiber officinale) on carbohydrate metabolism in streptozotocin-induced diabetic rats. British Journal of Nutrition, 12. pp. 1-8. ISSN 0007-1145 http://dx.doi.org/10.1017/S0007114511006635 10.1017/S0007114511006635
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QP Physiology
spellingShingle	QP Physiology Abdulrazaq, Nafiu Bidemi Cho, Maung Maung Win, Ni Ni Zaman, Rahela Rahman, Mohammad Tariqur Beneficial effects of ginger (Zingiber officinale) on carbohydrate metabolism in streptozotocin-induced diabetic rats
description	Zingiber officinale (ZO), commonly known as ginger, has been traditionally used in the treatment of diabetes mellitus. Several studies have reported the hypoglycaemic properties of ginger in animal models. The present study evaluated the antihyperglycaemic effect of its aqueous extract administered orally (daily) in three different doses (100, 300, 500 mg/kg body weight) for a period of 30 d to streptozotocin (STZ)-induced diabetic rats. A dose-dependent antihyperglycaemic effect revealed a decrease of plasma glucose levels by 38 and 68 % on the 15th and 30th day, respectively, after the rats were given 500 mg/kg. The 500 mg/kg ZO significantly (P < 0·05) decreased kidney weight (% body weight) in ZO-treated diabetic rats v. control rats, although the decrease in liver weight (% body weight) was not statistically significant. Kidney glycogen content increased significantly (P < 0·05) while liver and skeletal muscle glycogen content decreased significantly (P < 0·05) in diabetic controls v. normal controls. ZO (500 mg/kg) also significantly decreased kidney glycogen (P < 0·05) and increased liver and skeletal muscle glycogen in STZ-diabetic rats when compared to diabetic controls. Activities of glucokinase, phosphofructokinase and pyruvate kinase in diabetic controls were decreased by 94, 53 and 61 %, respectively, when compared to normal controls; and ZO significantly increased (P < 0·05) those enzymes' activities in STZ-diabetic rats. Therefore, the present study showed that ginger is a potential phytomedicine for the treatment of diabetes through its effects on the activities of glycolytic enzymes
format	Article
author	Abdulrazaq, Nafiu Bidemi Cho, Maung Maung Win, Ni Ni Zaman, Rahela Rahman, Mohammad Tariqur
author_facet	Abdulrazaq, Nafiu Bidemi Cho, Maung Maung Win, Ni Ni Zaman, Rahela Rahman, Mohammad Tariqur
author_sort	Abdulrazaq, Nafiu Bidemi
title	Beneficial effects of ginger (Zingiber officinale) on carbohydrate metabolism in streptozotocin-induced diabetic rats
title_short	Beneficial effects of ginger (Zingiber officinale) on carbohydrate metabolism in streptozotocin-induced diabetic rats
title_full	Beneficial effects of ginger (Zingiber officinale) on carbohydrate metabolism in streptozotocin-induced diabetic rats
title_fullStr	Beneficial effects of ginger (Zingiber officinale) on carbohydrate metabolism in streptozotocin-induced diabetic rats
title_full_unstemmed	Beneficial effects of ginger (Zingiber officinale) on carbohydrate metabolism in streptozotocin-induced diabetic rats
title_sort	beneficial effects of ginger (zingiber officinale) on carbohydrate metabolism in streptozotocin-induced diabetic rats
publisher	Cambridge University Press
publishDate	2011
url	http://irep.iium.edu.my/10548/ http://irep.iium.edu.my/10548/ http://irep.iium.edu.my/10548/ http://irep.iium.edu.my/10548/1/BJN_PUBLICATION_2011.pdf
first_indexed	2023-09-18T20:19:57Z
last_indexed	2023-09-18T20:19:57Z
_version_	1777408039903559680

Beneficial effects of ginger (Zingiber officinale) on carbohydrate metabolism in streptozotocin-induced diabetic rats

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