Blood pressure reduction following bilateral adrenal demedullation of young spontaneously hypertensive rats; comparison between normal saline and distilled water supplementation postoperatively

Blood pressure reduction following bilateral adrenal demedullation of young spontaneously hypertensive rats; comparison between normal saline and distilled water supplementation postoperatively

Normal saline (0.9% NaCl) supplementation is recommended to replace sodium loss in adrenal demedullation postoperatively . We propose that normal saline supplementation is not required postoperatively following adrenal demedullation. Twenty four young male and female SHRs weighing 200-270g and 150-1...

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Main Authors: Mohd Noor, Noriah, Abdullah, Aszrin, Abdul Razak, Tariq
Format: Conference or Workshop Item
Language:English
Published: 2011
Subjects:
R Medicine (General)
Online Access:http://irep.iium.edu.my/10195/
http://irep.iium.edu.my/10195/
http://irep.iium.edu.my/10195/2/BP_reduction_adrenal_demedullation.pdf
id iium-10195
recordtype eprints
spelling iium-101952012-02-23T02:25:50Z http://irep.iium.edu.my/10195/ Blood pressure reduction following bilateral adrenal demedullation of young spontaneously hypertensive rats; comparison between normal saline and distilled water supplementation postoperatively Mohd Noor, Noriah Abdullah, Aszrin Abdul Razak, Tariq R Medicine (General) Normal saline (0.9% NaCl) supplementation is recommended to replace sodium loss in adrenal demedullation postoperatively . We propose that normal saline supplementation is not required postoperatively following adrenal demedullation. Twenty four young male and female SHRs weighing 200-270g and 150-170g, respectively were studied. Six were sham-operated age-matched controls (Group 1) were given distilled, 10 adrenal demedullated SHRs were given 0.9% NaCl supplementation (Group 2) and 8 adrenal demedullated SHRs were given distilled water (Group 3). Indirect systolic blood pressures (SBPs) was measured by tail cuff method preoperatively,1 week and 2 weeks postoperatively. The mean preoperative SBP in Groups 1, 2 and 3 were 168.78 + 5.80, 164.05 + 17.11 and 163.15 + 16.26 mmHg respectively. The mean postoperative SBP at 1 week were 170.00 + 9.61, 132.79 + 19.91 and 128.31 + 19.36 mmHg respectively (p values of 0.753, 0.005 and 0.012, Wilcoxon Signed Ranks Test - compaired to preoperative mean values). The mean postoperative SBP at 2 weeks were 167.08 + 6.87, 138.50 + 17.73 and 129.00 + 13.34 mmHg respectively (p values of 0.753, 0.005 and 0.028, Wilcoxon Signed Ranks Test). There was no significant difference in the mean values between Groups 2 and 3 at 1 week and 2 weeks postoperatively (p values of 0.423 and 0.278, Mann-Whitney U). Adrenal demedullation results in chronic SBP reduction in SHRs given normal saline or distilled water postoperatively. Therefore, ad libitum normal saline supplementation is not essential in postoperative, adrenal demedullated SHRs as there is minimal adrenal cortical damage during demedullation 2011-09-11 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/10195/2/BP_reduction_adrenal_demedullation.pdf Mohd Noor, Noriah and Abdullah, Aszrin and Abdul Razak, Tariq (2011) Blood pressure reduction following bilateral adrenal demedullation of young spontaneously hypertensive rats; comparison between normal saline and distilled water supplementation postoperatively. In: The 7th Congress of the Federation of Asian and Oceanian Physiological Societies, 11-14 September 2011, Taipei, Taiwan. http://faops.org.my
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic R Medicine (General)
spellingShingle R Medicine (General)
Mohd Noor, Noriah
Abdullah, Aszrin
Abdul Razak, Tariq
Blood pressure reduction following bilateral adrenal demedullation of young spontaneously hypertensive rats; comparison between normal saline and distilled water supplementation postoperatively
description Normal saline (0.9% NaCl) supplementation is recommended to replace sodium loss in adrenal demedullation postoperatively . We propose that normal saline supplementation is not required postoperatively following adrenal demedullation. Twenty four young male and female SHRs weighing 200-270g and 150-170g, respectively were studied. Six were sham-operated age-matched controls (Group 1) were given distilled, 10 adrenal demedullated SHRs were given 0.9% NaCl supplementation (Group 2) and 8 adrenal demedullated SHRs were given distilled water (Group 3). Indirect systolic blood pressures (SBPs) was measured by tail cuff method preoperatively,1 week and 2 weeks postoperatively. The mean preoperative SBP in Groups 1, 2 and 3 were 168.78 + 5.80, 164.05 + 17.11 and 163.15 + 16.26 mmHg respectively. The mean postoperative SBP at 1 week were 170.00 + 9.61, 132.79 + 19.91 and 128.31 + 19.36 mmHg respectively (p values of 0.753, 0.005 and 0.012, Wilcoxon Signed Ranks Test - compaired to preoperative mean values). The mean postoperative SBP at 2 weeks were 167.08 + 6.87, 138.50 + 17.73 and 129.00 + 13.34 mmHg respectively (p values of 0.753, 0.005 and 0.028, Wilcoxon Signed Ranks Test). There was no significant difference in the mean values between Groups 2 and 3 at 1 week and 2 weeks postoperatively (p values of 0.423 and 0.278, Mann-Whitney U). Adrenal demedullation results in chronic SBP reduction in SHRs given normal saline or distilled water postoperatively. Therefore, ad libitum normal saline supplementation is not essential in postoperative, adrenal demedullated SHRs as there is minimal adrenal cortical damage during demedullation
format Conference or Workshop Item
author Mohd Noor, Noriah
Abdullah, Aszrin
Abdul Razak, Tariq
author_facet Mohd Noor, Noriah
Abdullah, Aszrin
Abdul Razak, Tariq
author_sort Mohd Noor, Noriah
title Blood pressure reduction following bilateral adrenal demedullation of young spontaneously hypertensive rats; comparison between normal saline and distilled water supplementation postoperatively
title_short Blood pressure reduction following bilateral adrenal demedullation of young spontaneously hypertensive rats; comparison between normal saline and distilled water supplementation postoperatively
title_full Blood pressure reduction following bilateral adrenal demedullation of young spontaneously hypertensive rats; comparison between normal saline and distilled water supplementation postoperatively
title_fullStr Blood pressure reduction following bilateral adrenal demedullation of young spontaneously hypertensive rats; comparison between normal saline and distilled water supplementation postoperatively
title_full_unstemmed Blood pressure reduction following bilateral adrenal demedullation of young spontaneously hypertensive rats; comparison between normal saline and distilled water supplementation postoperatively
title_sort blood pressure reduction following bilateral adrenal demedullation of young spontaneously hypertensive rats; comparison between normal saline and distilled water supplementation postoperatively
publishDate 2011
url http://irep.iium.edu.my/10195/
http://irep.iium.edu.my/10195/
http://irep.iium.edu.my/10195/2/BP_reduction_adrenal_demedullation.pdf
first_indexed 2023-09-18T20:19:37Z
last_indexed 2023-09-18T20:19:37Z
_version_ 1777408019509805056

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